178 papers
In a longitudinal study of individuals at clinical high risk for psychosis, current tobacco and cannabis use predicted increased future anxiety, while heavier baseline cannabis use was associated with slower improvement in negative symptoms and greater role function deterioration.
This randomized controlled feasibility study demonstrates that at-home Microtesla Magnetic Therapy is a safe, feasible, and well-tolerated intervention that yields preliminary evidence of significant improvements in cognitive function and mood for individuals with post-acute sequelae of SARS-CoV-2.
This cross-sectional study provides preliminary evidence that Post-Traumatic Stress Disorder is associated with systemic and cellular immunometabolic alterations, specifically characterized by heightened glycolysis and oxidative pentose phosphate pathway activity alongside elevated interleukin-6 levels, despite comparable inflammatory gene expression.
This study replicates findings from Norway by demonstrating that the educational attainment gap between students with ADHD or internalising disorders and their peers in South East London has narrowed over time, a trend that cannot be explained by an earlier age at first diagnosis.
This study identifies baseline DNA methylation markers associated with cognitive-behavioral therapy response in obsessive-compulsive disorder, suggesting that while stable epigenetic patterns linked to treatment outcomes are likely driven by genetic factors, longitudinal changes are significantly confounded by medication use and psychiatric comorbidities.
This study of young adults reveals that the negative associations between substance use and global brain thickness reflect a combination of substance-general and substance-specific effects, driven by both environmental exposure (particularly for alcohol and marijuana) and predispositional genetic risk (specifically for marijuana).
This study demonstrates that benchmark scores for language models' clinical safety are highly sensitive to configuration choices and measurement limitations, often yielding misleading results that require mental health professionals to apply their expertise in assessment interpretation to ensure accurate evaluation of AI systems.
This systematic review and meta-analysis of 33 studies found no significant association between retinal thickness abnormalities and anxiety, depression, or substance use disorders, highlighting substantial heterogeneity and publication bias that currently limit the utility of optical coherence tomography as a reliable biomarker for these conditions.
This study utilizes Mixed Graphical Models to map the non-clinical eating behaviors of 1,508 Indians, revealing that unlike Western body-image-centric models, the Indian network is a small-world system primarily anchored by structural and cultural factors (such as religion and home type) and integrated by a socio-economic bridge of employment, education, and self-esteem.
This study validates the Japanese version of the Family Stigma Instrument (J-FAMSI-dementia) for assessing dementia-related stigma among family caregivers, demonstrating its acceptable reliability, validity, and five-factor structure through a survey of 372 informal caregivers.
This UK qualitative study utilizing Leventhal's Common-Sense Model reveals that older adults' beliefs about anxiety are shaped more by individual salient identities and the distress level of their condition than by broad cultural categories, highlighting the need for nuanced, person-centred approaches to address underdiagnosis and low service utilization.
This study successfully translated and psychometrically validated the Mental Illness: Clinicians Attitudes Scale (MICA-4) into Urdu for use among primary care physicians in Pakistan, identifying a three-factor structure that supports its cautious application despite some limitations in internal consistency and cross-cultural stability.
This study of 320 stateless Liberian and Sierra Leonean refugee children in Nigeria reveals that while witnessed trauma is the strongest predictor of functional impairment, maintaining heritage-language competence and bilingual proficiency serves as a protective factor against PTSD-related disability, whereas CPTSD is more heavily influenced by cumulative relational trauma.
This smartphone-based study involving 96 healthy individuals demonstrates that the ability to reflect on one's own bodily states (body reflective functioning), rather than general mentalizing abilities, significantly predicts and explains somatic symptom burden in daily life, highlighting it as a novel target for early intervention strategies.
This cross-sectional study of young women demonstrates that long-term diet quality is the primary dietary driver of anxiety, which is significantly associated with specific gut microbiome features, including the presence of *Ruminococcus gnavus* and *Flavonifractor plautii* and reduced levels of butyrate and GABA synthesis pathways.
This 5-year follow-up study of first-episode psychosis patients demonstrates that negative symptoms are best conceptualized as two stable, distinct dimensions—Diminished Expression and Amotivation/Apathy—with Amotivation/Apathy showing superior predictive value for long-term functional outcomes compared to a unitary negative symptom construct.
This cross-sectional study of 407 patients at Gulu Regional Referral Hospital in post-conflict northern Uganda reveals a high lifetime prevalence (63.4%) of Complementary and Alternative Medicine use—primarily herbal, spiritual, and traditional practices—driven by cultural beliefs and social recommendations, with significant associations to education, residence, marital status, and religion, highlighting an urgent need for integration into formal mental health care due to low reporting rates to providers.
This study of the Arao cohort demonstrates that while serum autotaxin levels are inversely associated with DHEAS, baseline autotaxin levels specifically predict longitudinal cognitive decline in older women, suggesting a potential role for autotaxin in age-related cognitive changes.
This double-blind randomized controlled trial demonstrates that five days of 10 Hz tACS in major depressive disorder induces a temporally distinct neural response characterized by early, transient reductions in functional connectivity on day two that precede later, robust decreases in frontal alpha power on day four, which are significantly associated with improved reward sensitivity.
This study protocol outlines a pragmatic, multi-site randomized controlled trial designed to evaluate the safety, clinical effectiveness, and cost-effectiveness of an 8-session outdoor swimming intervention added to usual care versus usual care alone for adults with major depression.